(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Base Information

Chemical Name:(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol
CAS No.:906076-87-7
Molecular Formula:C₂₁H₃₄O₄SSi
Molecular Weight:410.65
Hs Code.:

Synonyms:(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Suppliers and Price of (1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

There total 8 articles about (1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 906076-66-2
((1S,2S,3R,7S)-6-Benzenesulfonyl-2-methyl-8-oxa-bicyclo[5.1.0]oct-5-en-3-yloxy)-tert-butyl-dimethyl-silane

: 75-16-1
methylmagnesium bromide

: 917-54-4
methyllithium

: 906076-60-6
((1R,2S)-5-Benzenesulfonyl-2-methyl-cyclohepta-3,5-dienyloxy)-tert-butyl-dimethyl-silane

: 906076-87-7
(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

: C₂₁H₃₄O₄SSi

Guidance literature:: methylmagnesium bromide; methyllithium; In diethyl ether; toluene; at 20 ℃; for 0.0833333h;

((1S,2S,3R,7S)-6-Benzenesulfonyl-2-methyl-8-oxa-bicyclo[5.1.0]oct-5-en-3-yloxy)-tert-butyl-dimethyl-silane; With copper(l) iodide; In diethyl ether; toluene; at -45 ℃; for 0.75h; Further stages.;
DOI:10.1021/ja071217x

Reference yield: 80.0%

: 906076-70-8
(1S,4R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-4-(3,5-dimethyl-pyrazol-1-yl)-7-methyl-cyclohept-2-enol

: 75-16-1
methylmagnesium bromide

: 906076-87-7
(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

: 906076-72-0
(1S,2S,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Guidance literature:: In tetrahydrofuran; diethyl ether; toluene; at -78 - 20 ℃; for 1h;
DOI:10.1021/ol060530l

Reference yield:

: 906076-60-6
((1R,2S)-5-Benzenesulfonyl-2-methyl-cyclohepta-3,5-dienyloxy)-tert-butyl-dimethyl-silane

: 906076-87-7
(1S,2R,6R,7S)-3-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2,7-dimethyl-cyclohept-3-enol

Guidance literature:: Multi-step reaction with 3 steps

1: urea*H₂O₂; Na₂CO₃; (CF₃CO)2O / CH₂Cl₂ / 1.5 h / 0 °C

2: 90 percent / toluene / 3 h / 65 °C

3: diethyl ether / 20 °C

With urea hydrogen peroxide adduct; sodium carbonate; trifluoroacetic anhydride; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja071217x