5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Base Information

Chemical Name:5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile
CAS No.:1431540-99-6
Molecular Formula:C₂₈H₂₄N₆O₃
Molecular Weight:492.537
Hs Code.:

Synonyms:5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Suppliers and Price of 5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Chemical Property:

Purity/Quality:: ≥98% by HPLC ^*data from raw suppliers

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Technology Process of 5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

There total 11 articles about 5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1073354-05-8
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile

: 1431542-27-6
1-{4-[3-(6-bromo-quinazolin-4-yl)-benzoyl]-piperazine-1-yl}-ethanone

: 1431540-99-6
5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos; In 1,4-dioxane; water; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201903464

Reference yield:

: 32084-59-6
6-bromoquinazolin-4(3H)-one

: 1431540-99-6
5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 140 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / acetonitrile; water / 0.25 h / 100 °C / Microwave irradiation

3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

4.2: 2 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1431540-99-6
5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

2.2: 2 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;