trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

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Chemical Name:trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide
CAS No.:1395921-44-4
Molecular Formula:C₂₂H₃₂N₂O₃
Molecular Weight:372.508
Hs Code.:

Synonyms:trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

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Chemical Property of trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

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Technology Process of trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

There total 7 articles about trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride

: 64-19-7,77671-22-8
acetic acid

: 1395921-44-4
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1395921-44-4
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6698-13-1
4-bromo-benzo[1,3]dioxole

: 1395921-44-4
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;