tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

Base Information

Chemical Name:tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate
CAS No.:179060-28-7
Molecular Formula:C₁₂H₁₇NO₃
Molecular Weight:223.272
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10465449
Wikidata:Q82291401
Mol file:179060-28-7.mol

Synonyms:179060-28-7;tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate;tert-Butyl 4,5-dihydrofuro[2,3-c]pyridine-6(7H)-carboxylate;tert-butyl 5,7-dihydro-4H-furo[2,3-c]pyridine-6-carboxylate;TERT-BUTYL4,7-DIHYDROFURO[2,3-C]PYRIDINE-6(5H)-CARBOXYLATE;Furo[2,3-c]pyridine-6(5H)-carboxylic acid, 4,7-dihydro-, 1,1-dimethylethyl ester;AAPUUGDFHOCKDP-UHFFFAOYSA-N;SCHEMBL5542914;DTXSID10465449;MFCD09038020;AKOS015909397;AS-80585;CS-0434783;E85020;6-(t-Butoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine;6-tert-butoxycarbonyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Suppliers and Price of tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-4,7-DIHYDROFURO[2,3-C]PYRIDINE-6(5H)-CARBOXYLATE 95.00%
5MG
$ 503.81

Alichem
tert-Butyl4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate
1g
$ 778.26

Total 8 raw suppliers

Chemical Property of tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

Chemical Property:

Boiling Point:309.5 °C at 760 mmHg
Flash Point:141 °C
PSA：42.68000
Density:1.131 g/cm³
LogP:2.51070
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:223.12084340
Heavy Atom Count:16
Complexity:272

Purity/Quality:

99% ^*data from raw suppliers

TERT-BUTYL-4,7-DIHYDROFURO[2,3-C]PYRIDINE-6(5H)-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC2=C(C1)OC=C2

Technology Process of tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate

There total 4 articles about tert-Butyl 4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 179060-29-8
2-(tert-butoxycarbonylamino)-1-(3-furyl)ethane

: 179060-28-7
6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 2h; Heating;
DOI:10.1021/jm049884d

Reference yield:

: 498-60-2
furan-3-carboxaldehyde

: 179060-28-7
6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / aq. NaOH / ethanol / 1 h / 0 °C

2: NaBH₄ / tetrahydrofuran / 2 h / 20 °C

3: 4.30 g / CH₂Cl₂ / 1 h

4: 45 percent / p-toluenesulfonic acid hydrate / toluene / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm049884d

Reference yield:

: 53916-75-9
2-(furan-3-yl)ethylamine

: 179060-28-7
6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 4.30 g / CH₂Cl₂ / 1 h

2: 45 percent / p-toluenesulfonic acid hydrate / toluene / 2 h / Heating

With toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1021/jm049884d