5-bromo-2-hydroxyisophthalic acid

Base Information

• Chemical Name: 5-bromo-2-hydroxyisophthalic acid
• CAS No.: 101495-45-8
• Molecular Formula: C₈H₅BrO₅
• Molecular Weight: 261.029
• Mol file: 101495-45-8.mol

Synonyms:5-bromo-2-hydroxyisophthalic acid

Chemical Property of 5-bromo-2-hydroxyisophthalic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-hydroxyisophthalic acid

There total 4 articles about 5-bromo-2-hydroxyisophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5-bromo-3-formyl-2-hydroxybenzoic acid (134948-41-7) → 5-bromo-2-hydroxyisophthalic acid (101495-45-8)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1002/chem.201803242

Reference yield:

5-bromosalicyclic acid (89-55-4) → 5-bromo-2-hydroxyisophthalic acid (101495-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 12 h / 90 °C

2: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; trifluoroacetic acid; In water; dimethyl sulfoxide;

DOI:10.1002/chem.201803242

Reference yield:

4-bromo-2,6-bis(hydroxymethyl)phenol (6296-63-5) → 5-bromo-2-hydroxyisophthalic acid (101495-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH / Behandeln des Reaktionsprodukts mit KMnO₄ und wss. KOH

With sodium hydroxide;

upstream raw materials:

5-bromo-2-methoxyisophthalic acid

4-bromo-2,6-bis(hydroxymethyl)phenol

5-bromosalicyclic acid

5-bromo-3-formyl-2-hydroxybenzoic acid