Technology Process of (3aR,6S,6aS)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester
There total 11 articles about (3aR,6S,6aS)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 72 percent / silver trifluoroacetate; N-methylmorpholine / tetrahydrofuran / 6 h / 0 - 20 °C
2.1: 67 percent / lithium borohydride / methanol; tetrahydrofuran / 1.25 h
3.1: 3.42 g / triethylamine / CH2Cl2 / 1 h / 0 °C
4.1: sodium azide / dimethylformamide / 1.5 h / 60 °C
5.1: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
6.1: sodium carbonate / dioxane; H2O / 1 h
7.1: meta-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 °C
8.1: hydrogen / Pd/C / ethanol / 0 - 20 °C
8.2: 61 percent / sodium carbonate / dioxane; H2O / 1 h
9.1: HCl / dioxane / 1.08 h / 20 °C
10.1: N-methylmorpholine / dimethylformamide / 1.75 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; lithium borohydride; sodium azide; hydrogen; silver trifluoroacetate; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
1.1: Wolff rearrangement / 6.1: Schotten-Baumann reaction / 8.2: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 3.42 g / triethylamine / CH2Cl2 / 1 h / 0 °C
2.1: sodium azide / dimethylformamide / 1.5 h / 60 °C
3.1: triphenylphosphine / tetrahydrofuran / 7.5 h / 45 °C
4.1: sodium carbonate / dioxane; H2O / 1 h
5.1: meta-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 °C
6.1: hydrogen / Pd/C / ethanol / 0 - 20 °C
6.2: 61 percent / sodium carbonate / dioxane; H2O / 1 h
7.1: HCl / dioxane / 1.08 h / 20 °C
8.1: N-methylmorpholine / dimethylformamide / 1.75 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; sodium azide; hydrogen; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
4.1: Schotten-Baumann reaction / 6.2: Schotten-Baumann reaction;
DOI:10.1016/j.bmc.2004.10.060
![(3aR,6S,6aS)-6-Hydroxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
