Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate

Base Information

Chemical Name:Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate
CAS No.:104007-10-5
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:
DSSTox Substance ID:DTXSID901151370
ChEMBL ID:CHEMBL599680
Mol file:104007-10-5.mol

Synonyms:104007-10-5;Propanedioic acid, 2-[[[4-(ethoxycarbonyl)phenyl]amino]methylene]-, 1,3-diethyl ester;CHEMBL599680;SCHEMBL10861454;DTXSID901151370;STK075113;AKOS003239339;diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate;diethyl ({[4-(ethoxycarbonyl)phenyl]amino}methylidene)propanedioate;1,3-Diethyl 2-[[[4-(ethoxycarbonyl)phenyl]amino]methylene]propanedioate

Suppliers and Price of Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:335.13688739
Heavy Atom Count:24
Complexity:446

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC=C(C=C1)NC=C(C(=O)OCC)C(=O)OCC

Technology Process of Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate

There total 2 articles about Diethyl 2-((4-(ethoxycarbonyl)phenylamino)methylene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 74-96-4
ethyl bromide

: 37520-73-3
2-[(4-carboxy-phenylamino)-methylene]-malonic acid diethyl ester

: 104007-10-5
2-[(4-ethoxycarbonyl-phenylamino)-methylene]-malonic acid diethyl ester

Guidance literature:: 2-[(4-carboxy-phenylamino)-methylene]-malonic acid diethyl ester; With potassium carbonate; In acetone; for 1h;

ethyl bromide; In acetone; for 24h;
DOI:10.1055/s-0031-1290449

Reference yield: 50.0%

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 94-09-7
p-aminoethylbenzoate

: 104007-10-5
2-[(4-ethoxycarbonyl-phenylamino)-methylene]-malonic acid diethyl ester

Guidance literature:: With formic acid; at 50 - 55 ℃;
DOI:10.1134/S1070363216110074

Reference yield: 85.0%

: 104007-10-5
2-[(4-ethoxycarbonyl-phenylamino)-methylene]-malonic acid diethyl ester

: 1415327-41-1
2-[(4-ethoxycarbonyl-phenylamino)-methylene]-malonic acid monoethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In chloroform; at 20 ℃; for 1.35h; chemoselective reaction; Inert atmosphere;
DOI:10.1055/s-0031-1290449