methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate
CAS No.:1445589-67-2
Molecular Formula:C₄₂H₅₁N₇O₇
Molecular Weight:765.91
Hs Code.:

methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

Synonyms:methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

There total 14 articles about methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1228553-33-0
[(S)-2-methyl-1-((S)-2-{5-[4-(4,4,5,5 tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester

: 1445590-82-8
((7R,8R)-8-(5-(4-bromophenyl)-1H-imidazol-2-yl)-1,4-dioxaspiro[4.4]nonan-7-yl)((R)-3-methylmorpholino)methanone

: 1445589-67-2
methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 110 ℃;

Reference yield:

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 1445589-67-2
methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0 °C

2: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 °C / Sealed tube

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; 1,2-dimethoxyethane / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water;

Reference yield:

: 1007882-04-3
(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1445589-67-2
methyl ((2S)-3-methyl-1-(2-(5-(4-(2-((7S,8S)-8-((R)-3-methylmorpholine-4-carbonyl)-1,4-dioxaspiro[4.4]nonan-7-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; 1,2-dimethoxyethane / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water;