methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate
• CAS No.: 1047652-03-8
• Molecular Formula: C₂₅H₄₀O₆
• Molecular Weight: 436.589
• Mol file: 1047652-03-8.mol

Synonyms:methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate

Chemical Property of methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate

There total 1 articles about methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-ketodeoxycholic acid (911-40-0) → methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate (1047652-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 2 h / Heating; Inert atmosphere

2: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 2: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1016/j.steroids.2013.03.004

Reference yield:

methanol (67-56-1) + methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate (1047652-03-8) → C26H44O7

Guidance literature:

With potassium hydroxide; In water; for 6h; Heating;

DOI:10.1021/jo800708m

Reference yield:

methyl 3α,12α-dihydroxy-8-oxa-7-keto-8a-homo-5β-cholan-24-oate (1047652-03-8) → 3α,12α-di(tert-butyldimethylsilyloxy)-7,24-diallyloxy-7,8-seco-5β-cholan-8α-ol (1351984-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C

3: potassium hydride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2011.10.108

upstream raw materials:

7-ketodeoxycholic acid

Downstream raw materials:

C₃₆H₇₂O₅Si₂

3α,12α-di(tert-butyldimethylsilyloxy)-7,24-diallyloxy-7,8-seco-5β-cholan-8α-ol