methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate

Base Information

• Chemical Name: methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate
• CAS No.: 231300-24-6
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 231300-24-6.mol

Synonyms:methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate

Chemical Property of methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate

There total 2 articles about methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(bromomethyl)propenoate (4224-69-5) → methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate (231300-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / petroleum ether; methanol / 12 h / Ambient temperature

2: 0.67 M aq. bleach / tetrahydrofuran / 3 h

With sodium hypochlorite; potassium carbonate; In tetrahydrofuran; methanol; Petroleum ether;

DOI:10.1021/jm980406a

Reference yield:

3-(hydroxyimino)methylbenzonitrile (64847-76-3) + methyl α-methoxymethylacrylate (25328-81-8) → methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate (231300-24-6)

Guidance literature:

With sodium hypochlorite; In tetrahydrofuran; for 3h; Yield given;

DOI:10.1021/jm980406a

Reference yield: 100.0%

methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate (231300-24-6) → 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylic acid (231300-25-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 0.583333h; Ambient temperature;

DOI:10.1021/jm980406a

upstream raw materials:

3-(hydroxyimino)methylbenzonitrile

methyl α-methoxymethylacrylate

methyl 2-(bromomethyl)propenoate

Downstream raw materials:

3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylic acid

5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<5-<2'-(tert-butylaminosulfonyl)phenyl>-2-pyridinyl>-4,5-dihydro-5-(3-methoxymethyl)-

3-(3-cyano-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyrimidin-2-yl]-amide