Methyl 2-(methoxymethyl)acrylate

Base Information

• Chemical Name: Methyl 2-(methoxymethyl)acrylate
• CAS No.: 25328-81-8
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• European Community (EC) Number: 853-632-1
• DSSTox Substance ID: DTXSID90447102
• Nikkaji Number: J434.472C
• Wikidata: Q82265895
• Mol file: 25328-81-8.mol

Synonyms:25328-81-8;methyl 2-(methoxymethyl)acrylate;Methyl 2-(methoxymethyl)prop-2-enoate;2-Propenoic acid, 2-(methoxymethyl)-, methyl ester;SCHEMBL352782;methyl alpha-methoxymethylacrylate;DTXSID90447102;LHXULFYZCPMBMS-UHFFFAOYSA-N;Methyl2-(methoxymethyl)prop-2-enoate;alpha-(Methoxymethyl)acrylic acid methyl ester;EN300-226792

Chemical Property of Methyl 2-(methoxymethyl)acrylate

Chemical Property:

• Boiling Point: 100-125 °C
• PSA: 35.53000
• Density: 0.983±0.06 g/cm3(Predicted)
• LogP: 0.36200
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 130.062994177
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

methyl2-(methoxymethyl)prop-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=C)C(=O)OC

Technology Process of Methyl 2-(methoxymethyl)acrylate

There total 10 articles about Methyl 2-(methoxymethyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 1,2-propanediene (463-49-0) + carbon monoxide (201230-82-2) → methyl α-methoxymethylacrylate (25328-81-8)

Guidance literature:

With hydrogenchloride; oxygen; copper dichloride; palladium dichloride; at 0 - 25 ℃; under 760 Torr;

DOI:10.1039/c39840000905

Reference yield: 77.0%

methanol (67-56-1) + methyl 2-hydroxymethylacrylate (15484-46-5) → methyl α-methoxymethylacrylate (25328-81-8)

Guidance literature:

With palladium dichloride; In 1,2-dimethoxyethane; at 50 ℃;

DOI:10.1016/0022-328X(94)80175-4

Reference yield: 58.0%

methyl 2-(bromomethyl)propenoate (4224-69-5) + sodium methylate (124-41-4) → methyl α-methoxymethylacrylate (25328-81-8)

Guidance literature:

With potassium carbonate; In methanol; Petroleum ether;

upstream raw materials:

methyl 2-(bromomethyl)propenoate

sodium methylate

(2-(methoxycarbonyl)allyl)triphenylphosphonium bromide

methanol

Downstream raw materials:

3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylic acid

5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<5-<2'-(tert-butylaminosulfonyl)phenyl>-2-pyridinyl>-4,5-dihydro-5-(3-methoxymethyl)-

3-(3-cyano-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyrimidin-2-yl]-amide