25328-81-8

Basic information

• Product Name: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester
• Synonyms: methyl 2-methoxymethylacrylate;2-(Methoxymethyl)acrylsaeure-methylester;2-Propenoic acid,2-(methoxymethyl)-,methyl ester
• CAS NO: 25328-81-8
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Mol File: 25328-81-8.mol

Chemical Properties

• Boiling Point: 100-125 °C
• Density: 0.983±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(25328-81-8)
• EPA Substance Registry System: 2-Propenoic acid, 2-(methoxymethyl)-, methyl ester(25328-81-8)

Safety Data

• Hazardous Substances Data: 25328-81-8(Hazardous Substances Data)

Upstream product

• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 124-41-4 sodium methylate 
• 72707-68-7 (2-(methoxycarbonyl)allyl)triphenylphosphonium bromide 
• 67-56-1 methanol 
• 463-49-0 1,2-propanediene 
• 201230-82-2 carbon monoxide 
• 15484-46-5 methyl 2-hydroxymethylacrylate 
• 107-19-7 propargyl alcohol 

Downstream Products

• 136328-26-2 3-Benzyl-4-methoxymethyl-4,5-dihydro-3H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 136328-27-3 1-Benzyl-4-methoxymethyl-4,5-dihydro-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 231300-24-6 methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate 
• 942189-76-6 methyl 1-benzyl-3-methoxymethyl-pyrrolidine-3-carboxylate 
• 1415690-15-1 C₁₇H₂₄O₆ 
• 1026711-32-9 3-(3-cyano-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyrimidin-2-yl]-amide 
• 231300-26-8 5-isoxazolecarboxamide, 3-(3-cyanophenyl)-N-<5-<2'-(tert-butylaminosulfonyl)phenyl>-2-pyridinyl>-4,5-dihydro-5-(3-methoxymethyl)- 
• 231300-25-7 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylic acid 

Relevant articles and documents

New insights into the alkoxycarbonylation of propargyl alcohol

The challenging carbonylation of propargyl alcohol is effectively catalyzed by Pd(OAc)2 in combination with diphenyl-(6-methyl-pyridin-2-yl)phosphine and methanesulfonic acid. In dichloroethane at 20–50 °C, the reaction affords with almost complete regioselectivity alkyl 2-(hydroxymethyl)acrylates. Turnover frequency numbers (TOF) of up to 450 h?1 can be achieved working at 50 °C, while a maximum turnover number (TON) of about 730 is obtained at 30 °C. The catalyst longevity is limited because the carbonylation product reacts with the phosphorus atom of the ligand to give a quaternary phosphonium salt. This reaction leads to deactivation of the catalyst and eventually to palladium black formation.

ALPHA-(UNSATURATED ALKOXYALKYL) ACRYLATE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF

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POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

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A direct oxidative methoxycarbonylation of propyne with carbon monoxide in methanol medium in the presence of copper-palladium catalytic system results in methyl 2-butynoate in 18-31% yield. Depending on reaction conditions allene provides either a mixture of methyl 2-(chloromethyl)acrylate and methyl 2-(methoxymethyl)acrylate (～3-4:1) in overall yield 16-23%, or methyl 2-(methoxymethyl)acrylate in 19% yield.

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The Alkoxy-Alkoxycarbonylation of Allenes

Allene undergoes alkoxy-alkoxycarbonylation under exceedingly mild conditions (CO-O2-MeOH-PdCl2-CuCl2, 0 deg C, 1 atm) affording methyl 2-methoxymethylacrylate in good yield; in the case of 1,1-disubstituted allenes the reaction is regiospecific although