6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

Base Information

Chemical Name:6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde
CAS No.:883221-03-2
Molecular Formula:C₂₂H₂₄O₆
Molecular Weight:384.429
Hs Code.:

Synonyms:6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

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Chemical Property of 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

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Technology Process of 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

There total 3 articles about 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 883221-01-0
1-bromo-6,7-dimethoxy-3,4-dihydronaphthalene-2-carbaldehyde

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 883221-03-2
6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; for 64h; Heating;
DOI:10.1016/j.tet.2006.01.013

Reference yield:

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 883221-03-2
6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: trimethylborate / tetrahydrofuran / 0.5 h / -78 °C

1.3: HCl / tetrahydrofuran; H₂O

2.1: 88 percent / sodium carbonate / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O; ethanol / 64 h / Heating

With n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2006.01.013

Reference yield:

: 13575-75-2
6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydronaphthalene

: 883221-03-2
6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus tribromide / CH₂Cl₂ / 2 h / 0 °C

1.2: 63 percent / CH₂Cl₂ / 12 h / Heating

2.1: 88 percent / sodium carbonate / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O; ethanol / 64 h / Heating

With phosphorus tribromide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2006.01.013