trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

Base Information

• Chemical Name: trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
• CAS No.: 93011-84-8
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 93011-84-8.mol

Synonyms:trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

Chemical Property of trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

There total 9 articles about trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

trans-7-tetrahydropyranyloxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one → trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one (93011-84-8)

Guidance literature:

With water; In acetic acid; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(00)00101-0

Reference yield:

(E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one (108838-39-7) → 7-hydroxy-3-methyl-2-phenyl-chroman-4-one (93011-84-8)

Guidance literature:

With hydrogenchloride; optically inactive stereoisomer(ic) of mp: 161 degree;

Reference yield:

benzaldehyde (100-52-7) → trans-7-hydroxy-3-methyl-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one (93011-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperidine / propan-2-ol / 48 h / Heating

1.2: 70 percent / DBU / propan-2-ol / 48 h / 20 °C

2.1: 87 percent / H₂O / acetic acid / 18 h / 20 °C

With piperidine; water; In acetic acid; isopropyl alcohol; 1.1: Condensation / 1.2: Isomerization / 2.1: Hydrolysis;

DOI:10.1016/S0040-4020(00)00101-0

upstream raw materials:

(E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one

(E)-2-methyl-3-phenylacryloyl chloride

recorcinol

benzaldehyde

Downstream raw materials:

7-acetoxy-3-methyl-2-phenyl-chroman-4-one