108838-39-7

Basic information

• Product Name: (E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one
• Synonyms: (E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one
• CAS NO: 108838-39-7
• Molecular Weight: 254.285
• Mol File: 108838-39-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one(108838-39-7)
• EPA Substance Registry System: (E)-1-(2,4-dihydroxyphenyl)-2-methyl-3-phenylprop-2-en-1-one(108838-39-7)

Safety Data

• Hazardous Substances Data: 108838-39-7(Hazardous Substances Data)

Upstream product

• 35086-87-4 (E)-2-methyl-3-phenylacryloyl chloride 
• 108-46-3 recorcinol 
• 5792-36-9 2',4'-dihydroxypropiophenone 
• 100-52-7 benzaldehyde 

Downstream Products

• 93011-84-8 7-hydroxy-3-methyl-2-phenyl-chroman-4-one 
• 109251-27-6 7-acetoxy-3-methyl-2-phenyl-chroman-4-one 

Relevant articles and documents

Synthesis and biological evaluation of α-methyl-chalcone for anti-cervical cancer activity

A series of 31 chalcones were synthesized and evaluated for anti-proliferative activity against the human cervical cancer cell lines (HeLa and SiHa). Compound 19, (E)-1-(2,4-dihydroxyphenyl)-3-(4-(dimethylamino) phenyl)-2-methylprop-2-en-1-one was found to be an effective anti-proliferative agent in HeLa and SiHa cells (IC50 = 0.035 μM). Compound 19 increased the percentage of apoptosis in a dose-dependent manner, as measured by Annexin V-FITC (fluorescein isothiocyanate)/(propidium iodide) PI staining. Molecular modeling studies of compound 19 showed that the most potent structure was docked at the yeast 20 S proteasome binding site (Protein Data Bank code-3E47) and was stabilized in the cavity by various hydrophobic and hydrogen bonding interactions.