Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate
• CAS No.: 131843-80-6
• Molecular Formula: C₂₄H₁₈ClN₃O₄
• Molecular Weight: 447.878
• Mol file: 131843-80-6.mol

Synonyms:Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate

Chemical Property of Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate

There total 5 articles about Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate (131843-78-2) → Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate (131843-80-6)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at -5 ℃; for 1h;

DOI:10.1002/hlca.19900730615

Reference yield: 70.0%

2-(2-Benzoyl-4-chloro-phenylazo)-2-[(2-chloro-acetyl)-phenyl-amino]-malonic acid dimethyl ester (131843-78-2) → Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate (131843-80-6)

Guidance literature:

With sodium methylate; In methanol; at 0 - 20 ℃;

Reference yield:

dimethyl phenylaminomalonate (35757-92-7) → Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate (131843-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / toluene / 17 h / 80 °C

2: 1.) 5 M aq. NaNO₂, HOAc, HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 10 deg C, 2.) 1 h, room temperature

3: 95 percent / 1 N NaOMe/MeOH / tetrahydrofuran / 1 h / -5 °C

With hydrogenchloride; methanol; sodium methylate; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; toluene;

DOI:10.1002/hlca.19900730615

upstream raw materials:

Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate

2-(2-Benzoyl-4-chloro-phenylazo)-2-[(2-chloro-acetyl)-phenyl-amino]-malonic acid dimethyl ester

dimethyl phenylaminomalonate

Dimethyl (2-Chloro-N-phenylacetamido)malonate

Downstream raw materials:

Methyl 7-Chloro-3,4-dihydro-4-oxo-3,5-diphenyl-1,2,4-triazino<1,6-a>indole-2-carboxylate