Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate

Base Information

• Chemical Name: Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate
• CAS No.: 131843-78-2
• Molecular Formula: C₂₆H₂₁Cl₂N₃O₆
• Molecular Weight: 542.375
• Mol file: 131843-78-2.mol

Synonyms:Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate

Chemical Property of Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate

There total 2 articles about Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl phenylaminomalonate (35757-92-7) → Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate (131843-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / toluene / 17 h / 80 °C

2: 1.) 5 M aq. NaNO₂, HOAc, HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 10 deg C, 2.) 1 h, room temperature

With hydrogenchloride; potassium carbonate; acetic acid; sodium nitrite; In toluene;

DOI:10.1002/hlca.19900730615

Reference yield:

Dimethyl (2-Chloro-N-phenylacetamido)malonate (131843-76-0) + 5-chloro-2-aminobenzophenone (719-59-5) → Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate (131843-78-2)

Guidance literature:

With hydrogenchloride; potassium carbonate; acetic acid; sodium nitrite; Yield given. Multistep reaction; 1.) 15 min, 10 deg C, 2.) 1 h, room temperature;

DOI:10.1002/hlca.19900730615

Reference yield: 95.0%

Dimethyl 2-<(2-Benzoyl-4-chlorophenyl)azo>-2-(2-chloro-N-phenylacetamido)malonate (131843-78-2) → Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate (131843-80-6)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at -5 ℃; for 1h;

DOI:10.1002/hlca.19900730615

upstream raw materials:

Dimethyl (2-Chloro-N-phenylacetamido)malonate

5-chloro-2-aminobenzophenone

dimethyl phenylaminomalonate

Downstream raw materials:

Methyl 7-Chloro-3,4-dihydro-4-oxo-3,5-diphenyl-1,2,4-triazino<1,6-a>indole-2-carboxylate

Methyl 1-(2-Benzoyl-4-chlorophenyl)-1,4,5,6-tetrahydro-5-oxo-4-phenyl-1,2,4-triazine-3-carboxylate