(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.:1447811-52-0
Molecular Formula:C₄₃H₆₅NO₇Si
Molecular Weight:736.077
Hs Code.:

(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Synonyms:(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Suppliers and Price of (S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

There total 7 articles about (S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1447811-51-9
methyl 6,6,7-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylate

: 4-Methoxy-1-[(1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

: 1447811-52-0
(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: methyl 6,6,7-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

4-Methoxy-1-[(1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride; With hydrogenchloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 21h; Inert atmosphere;
DOI:10.1021/ja405547f

Reference yield:

: 562-13-0
2,2-dimethyl-1,3-cyclohexanedione

: 1447811-52-0
(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: camphor-10-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 72 h / 0 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 16 h / Inert atmosphere; Reflux

2.2: 0 °C

3.1: sodium hydride / mineral oil; diethyl ether / 1.5 h / 0 °C / Inert atmosphere

3.2: 6.5 h / 0 °C / Inert atmosphere

4.1: copper(l) cyanide / diethyl ether / 0.17 h / -50 °C / Inert atmosphere

4.2: 16 h / -35 - 20 °C / Inert atmosphere

5.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

5.3: 21 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; camphor-10-sulfonic acid; copper(l) cyanide; sodium hydride; diisopropylamine; orthoformic acid triethyl ester; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; mineral oil;
DOI:10.1021/ja405547f

Reference yield:

: 1447811-51-9
methyl 6,6,7-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylate

: 4-Methoxy-1-[(1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

: 1447811-52-0
(S)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

: (R)-(1S,2R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((8-(methoxycarbonyl)-6,6-dimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl)methyl)-4-oxo-5-(triisopropylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: methyl 6,6,7-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylate; With zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

4-Methoxy-1-[(1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃; Overall yield = 66 %; Overall yield = 9.30 g; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja5074646