Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI)
• CAS No.: 178033-26-6
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.155
• Mol file: 178033-26-6.mol

Synonyms:Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI)

There total 15 articles about Cyclopropanecarboxylic acid, 2-acetyl-, methyl ester, (1R-cis)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one (116910-14-6) → (1S,2R)-2-Acetyl-cyclopropanecarboxylic acid methyl ester (116949-58-7,178033-26-6)

Guidance literature:

With sulfuric acid; In methanol; for 96h; Heating;

DOI:10.1021/ja00229a067

Reference yield: 88.0%

methanol (67-56-1) + (1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one (116910-14-6) → (1S,2R)-2-Acetyl-cyclopropanecarboxylic acid methyl ester (116949-58-7,178033-26-6)

Guidance literature:

With sulfuric acid; for 96h; Heating;

DOI:10.1016/S0040-4020(01)85604-0

Reference yield:

(3S,7aR)-3-isopropyl-7a-methyltetrahydropyrrolo[2,1-b][1,3]-oxazol-5-one (98203-44-2) → (1S,2R)-2-Acetyl-cyclopropanecarboxylic acid methyl ester (116949-58-7,178033-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA/PhSeBr, 2.) H₂O₂

2: 64 percent

3: 88 percent / 10percent H₂SO₄ / methanol / 96 h / Heating

With sulfuric acid; Phenylselenyl bromide; dihydrogen peroxide; lithium diisopropyl amide; In methanol;

DOI:10.1021/ja00229a067

upstream raw materials:

methanol

(1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one

(1S,2R)-2-Acetyl-cyclopropanecarboxylic acid methyl ester

(3S,7aR)-3-isopropyl-7a-methyltetrahydropyrrolo[2,1-b][1,3]-oxazol-5-one

Downstream raw materials:

trans-2-Acetylcyclopropan-1-carbonsaeuremethylester