t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

Base Information

Chemical Name:t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate
CAS No.:87250-62-2
Molecular Formula:C₃₄H₄₂N₂O₁₀
Molecular Weight:638.715
Hs Code.:

Synonyms:t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

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Chemical Property of t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

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Technology Process of t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

There total 5 articles about t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4949-45-5
benzyl 2-methylacetoacetate

: 87250-62-2
t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.)isoamyl nitrite 2.)AcOH, NH₄OAc, Zn / 1.)0 degC to room temp. 2.)CCl₄ 90-100 deg C, 3 h

2: 75 percent / Tl(III)nitrate trihydrate, HNO₃ / methanol; CH₂Cl₂ / 24 h / Ambient temperature

3: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

4: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

With sodium tetrahydroborate; ammonium acetate; nitric acid; acetic anhydride; toluene-4-sulfonic acid; acetic acid; thallium(III) nitrate; zinc; isopentyl nitrite; In methanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)88706-8

Reference yield:

: 87238-27-5
benzyl 4-acetyl-3-ethyl-5-methylpyrrole-2-carboxylate

: 87250-62-2
t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Tl(III)nitrate trihydrate, HNO₃ / methanol; CH₂Cl₂ / 24 h / Ambient temperature

2: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

3: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

With sodium tetrahydroborate; nitric acid; acetic anhydride; toluene-4-sulfonic acid; thallium(III) nitrate; In methanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)88706-8

Reference yield:

: 87238-28-6
benzyl 3-ethyl-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

: 87250-62-2
t-butyl 5'-benzyloxycarbonyl-4'-ethyl-3-(2-methoxycarbonylethyl)-4,3'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

2: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

With sodium tetrahydroborate; acetic anhydride; toluene-4-sulfonic acid; In acetic acid;
DOI:10.1016/S0040-4020(01)88706-8