(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

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Chemical Name:(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone
CAS No.:553632-78-3
Molecular Formula:C₂₃H₁₉ClN₄O₄S
Molecular Weight:482.947
Hs Code.:

Synonyms:(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

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Chemical Property of (7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

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Technology Process of (7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

There total 3 articles about (7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 343633-12-5
7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 553632-78-3
(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

Guidance literature:: 7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine; With LDA-THF; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Cooling with acetone-dry ice;

4-morpholinocarbonyl chloride; In tetrahydrofuran; cyclohexane; for 1.5h;

Reference yield:

: C₁₂H₈ClN₃*ClH

: 553632-78-3
(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.33 h / 0 °C

1.2: 4 h

2.1: LDA-THF / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Cooling with acetone-dry ice

2.2: 1.5 h

With LDA-THF; sodium hydride; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; oil;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 553632-78-3
(7-benzenesulfonyl-4-chloro-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.33 h / 0 °C

1.2: 4 h

2.1: LDA-THF / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Cooling with acetone-dry ice

2.2: 1.5 h

With LDA-THF; sodium hydride; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; oil;