phorbol 12-phenylacetate 13-acetate 20-tritylether

Base Information

• Chemical Name: phorbol 12-phenylacetate 13-acetate 20-tritylether
• CAS No.: 179258-27-6
• Molecular Formula: C₄₉H₅₀O₈
• Molecular Weight: 766.931
• Mol file: 179258-27-6.mol

Synonyms:phorbol 12-phenylacetate 13-acetate 20-tritylether

Chemical Property of phorbol 12-phenylacetate 13-acetate 20-tritylether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phorbol 12-phenylacetate 13-acetate 20-tritylether

There total 3 articles about phorbol 12-phenylacetate 13-acetate 20-tritylether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

acetic acid (64-19-7,77671-22-8) + phorbol 13-phenylacetate-20-trityl (179258-40-3) → Phenyl-acetic acid (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9a-trihydroxy-1,1,6,8-tetramethyl-5-oxo-3-trityloxymethyl-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl ester + phorbol 12-phenylacetate 13-acetate 20-tritylether (179258-27-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm960063l

Reference yield:

phorbol-20-trityl ether (82400-03-1) → phorbol 12-phenylacetate 13-acetate 20-tritylether (179258-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran

2: dicyclohexylcarbodiimide / dimethylaminopyridine

With dicyclohexyl-carbodiimide; dmap; triethylamine; In tetrahydrofuran; 1: Acetylation / 2: Esterification;

DOI:10.1016/0014-2999(95)00864-0

Reference yield:

phenylacetic acid (103-82-2) + phorbol 13-acetate 20-tritylether (82389-25-1) → phorbol 12-phenylacetate 13-acetate 20-tritylether (179258-27-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/jm960063l

upstream raw materials:

phenylacetic acid

phorbol 13-acetate 20-tritylether

acetic acid

phorbol 13-phenylacetate-20-trityl

Downstream raw materials:

phorbol 12-phenylacetate 13-acetate 20-(MEM-homovanillate)

PPAHV

phorbol 12-phenylacetate 13-acetate