(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

Base Information

Chemical Name:(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid
CAS No.:443150-03-6
Molecular Formula:C₂₀H₃₀N₂O₅
Molecular Weight:378.469
Hs Code.:

Synonyms:(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

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Chemical Property of (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

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Technology Process of (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

There total 5 articles about (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 443149-93-7
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

: 443150-03-6
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo0110698

Reference yield:

: 126395-29-7
[(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 443150-03-6
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

2.1: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

3.1: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

4.1: HCl / methanol / 0.75 h / 20 °C

4.2: 462 mg / N-methylmorpholine / tetrahydrofuran / 20 °C

5.1: 88 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; triethylamine; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 153923-41-2
(S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate

: 443150-03-6
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

2.1: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

3.1: HCl / methanol / 0.75 h / 20 °C

3.2: 462 mg / N-methylmorpholine / tetrahydrofuran / 20 °C

4.1: 88 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698