(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

Base Information

Chemical Name:(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester
CAS No.:443149-93-7
Molecular Formula:C₂₄H₃₈N₂O₅
Molecular Weight:434.576
Hs Code.:

Synonyms:(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

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Chemical Property of (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

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Technology Process of (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

There total 5 articles about (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126395-29-7
[(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 443149-93-7
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

2.1: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

3.1: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

4.1: HCl / methanol / 0.75 h / 20 °C

4.2: 462 mg / N-methylmorpholine / tetrahydrofuran / 20 °C

With hydrogenchloride; sodium azide; hydrogen; triethylamine; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 153923-41-2
(S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate

: 443149-93-7
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

2.1: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

3.1: HCl / methanol / 0.75 h / 20 °C

3.2: 462 mg / N-methylmorpholine / tetrahydrofuran / 20 °C

With hydrogenchloride; sodium azide; hydrogen; 10percent Pd/C; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 443149-91-5
N-[(1S)-2-azido-1-(4-methoxyphenylmethyl)ethyl](tert-butoxy)carboxamide

: 443149-93-7
(3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

2.1: HCl / methanol / 0.75 h / 20 °C

2.2: 462 mg / N-methylmorpholine / tetrahydrofuran / 20 °C

With hydrogenchloride; hydrogen; 10percent Pd/C; In methanol;
DOI:10.1021/jo0110698