3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

Base Information

Chemical Name:3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate
CAS No.:1453267-85-0
Molecular Formula:C₁₈H₂₀ClN₃O₃
Molecular Weight:361.828
Hs Code.:

Synonyms:3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

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Chemical Property of 3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

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Technology Process of 3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

There total 15 articles about 3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453267-84-9
3-(3-chloro-4-cyano-2-methylphenyl)-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

: 74-88-4
methyl iodide

: 1453267-85-0
3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 4065-92-3,86703-52-8
cyclopentane-1,2-diol

: 1453267-85-0
3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 24 h / 20 °C

2.1: Jones reagent / acetone / 0 °C

3.1: ammonium chloride / water; ethanol / 15 h / 20 °C

3.2: 48 h / 100 °C

4.1: sodium hydroxide / 19 h / 100 °C / Sealed tube

4.2: 18 h / 20 °C

5.1: diethyl ether / 0.5 h / 0 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

7.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C

7.2: 0 - 20 °C

8.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C

9.1: acetic acid / methanol / 0 - 20 °C

9.2: 16 h / 0 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

11.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

12.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

13.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

14.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; Jones reagent; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1453267-80-5
tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

: 1453267-85-0
3-(3-chloro-4-cyano-2-methylphenyl)-1-methyl-2-oxo-1,3-diazaspiro[4.4]nonan-6-yl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: dmap; triethylamine / dichloromethane / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

5: sodium hydride / tetrahydrofuran / 0 - 20 °C

With dmap; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;