ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE
• CAS No.: 943863-69-2
• Molecular Formula: C₁₃H₁₃FN₂O₂
• Molecular Weight: 248.257
• Mol file: 943863-69-2.mol

Synonyms:1-methyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester

Chemical Property of ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE

There total 4 articles about ETHYL 3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (866588-11-6) + dimethyl sulfate (77-78-1) → 1-methyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (943863-69-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1097/CAD.0000000000000322

Reference yield:

ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate, sodium salt + methylhydrazine (60-34-4) → 5-(4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (871362-68-4) + 1-methyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (943863-69-2)

Guidance literature:

With acetic acid; In ethanol; for 3.5h;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 1-methyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (943863-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 80 °C

2: hydrazine hydrate; acetic acid / ethanol / 3 h / 90 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 °C

With sodium ethanolate; sodium hydride; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1097/CAD.0000000000000322

upstream raw materials:

methylhydrazine

1-(4-fluorophenyl)ethanone

(Z)-ethyl 4-(4-fluorophenyl)-2-hydroxy-4-oxobut-2-enoate

3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester

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