3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 866588-11-6
• Molecular Formula: C12H11FN2O2
• Molecular Weight: 234.23
• Hs Code.: 2933199090
• Mol file: 866588-11-6.mol

Synonyms:3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 2.11E-07mmHg at 25°C
• Refractive Index: 1.559
• Boiling Point: 424.2°C at 760 mmHg
• Flash Point: 210.3°C
• PSA: 54.98000
• Density: 1.266g/cm³
• LogP: 2.39250

Purity/Quality:

98% ^*data from raw suppliers

ethyl5-(4-fluorophenyl)-1H-pyrazole-3-carboxylate 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 11 articles about 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate (31686-94-9) → 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (866588-11-6)

Guidance literature:

With hydrazine; In ethanol; for 1h; Heating / reflux;

Reference yield: 98.0%

C12H11FO4 → ethyl 5-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (866588-11-6)

Guidance literature:

With semicarbazide hydrochloride; In water; for 2h; Reflux; Green chemistry;

DOI:10.1039/c4gc02028f

Reference yield: 96.0%

C14H14FNO6 (1450626-62-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester (866588-11-6)

Guidance literature:

With sodium carbonate; In methanol; at 65 ℃; for 2h; regioselective reaction;

DOI:10.1016/j.tet.2013.12.046

upstream raw materials:

oxalic acid diethyl ester

ethanol

5-(4-fluoro-phenyl)-1H-pyrazole-3-carboxylic acid

1-(4-fluorophenyl)ethanone

Downstream raw materials:

ethyl 5-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate