(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

Base Information

Chemical Name:(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene
CAS No.:210684-36-9
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

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Chemical Property of (S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

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Technology Process of (S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

There total 6 articles about (S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-88-4
methyl iodide

: (4,2'-Dimethoxy-biphenyl-3-yl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone

: 210684-36-9
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

Guidance literature:: (4,2'-Dimethoxy-biphenyl-3-yl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 5h; Heating;
DOI:10.1021/jo0490853

Reference yield:

: 5720-06-9
2-Methoxyphenylboronic acid

: 210684-36-9
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84 percent / Na₂CO₃; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / methanol; toluene; H₂O / Heating

2.1: 93 percent / aq. KOH / methanol / Heating

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 5 h / 20 °C

3.2: Et₃N / CH₂Cl₂ / -40 - 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: 11.38 g / tetrahydrofuran / 5 h / Heating

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo0490853

Reference yield:

: 40757-09-3
methyl 2-methoxy-5-iodobenzoate

: 210684-36-9
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-5-[(2'-methoxy)phenyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84 percent / Na₂CO₃; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / methanol; toluene; H₂O / Heating

2.1: 93 percent / aq. KOH / methanol / Heating

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 5 h / 20 °C

3.2: Et₃N / CH₂Cl₂ / -40 - 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: 11.38 g / tetrahydrofuran / 5 h / Heating

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo0490853