4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

Base Information

Chemical Name:4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine
CAS No.:1338581-58-0
Molecular Formula:C₁₇H₁₅FN₄
Molecular Weight:294.331
Hs Code.:

Synonyms:4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

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Chemical Property of 4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

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Technology Process of 4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

There total 8 articles about 4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1095708-32-9
N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester

: 1429654-69-2
3-bromo-2-(4-fluorophenyl)-5 ,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

: 1338581-58-0
4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

Guidance literature:: With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 150 ℃; for 0.2h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 1195995-72-2
4-(4,4,5 ,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)pyridin-2-amine

: 1429654-69-2
3-bromo-2-(4-fluorophenyl)-5 ,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

: 1338581-58-0
4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; water; toluene; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 671182-33-5
1-(4-fluorophenyl)-6-hydroxyhexane-1,3-dione

: 1338581-58-0
4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 1.5 h / 20 - 35 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 10 - 20 °C

3: sodium hydride; sodium iodide / mineral oil; N,N-dimethyl-formamide / 1.5 h / 10 - 20 °C

4: N-Bromosuccinimide / chloroform / 17 h / 0 - 20 °C

5: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium carbonate / 1,4-dioxane / 0.2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With N-Bromosuccinimide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium hydride; sodium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil;