N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

Base Information

Chemical Name:N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine
CAS No.:190846-25-4
Molecular Formula:C₂₅H₃₈N₂O₅
Molecular Weight:446.587
Hs Code.:

Synonyms:N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

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Chemical Property of N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

There total 6 articles about N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 190846-23-2
N-benzyloxycarbonyl-2(S)-(2-methanesulfonyloxyethyl)piperidine

: 190846-25-4
N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

Guidance literature:: t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; for 2h;

N-benzyloxycarbonyl-2(S)-(2-methanesulfonyloxyethyl)piperidine; In N,N-dimethyl-formamide; for 18h; Further stages.;
DOI:10.1021/jm011133d

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 190846-25-4
N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / CH₂Cl₂ / 56 h / 23 °C

2.1: NaH / dimethylformamide / 2 h

2.2: 61 percent / dimethylformamide / 18 h

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011133d

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 190846-25-4
N-benzyloxycarbonyl-2(S)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / Et₃N / CH₂Cl₂ / 18 h / 23 °C

2.1: 93 percent / Et₃N / CH₂Cl₂ / 0.42 h / 17 °C

3.1: NaH / dimethylformamide / 2 h

3.2: 61 percent / dimethylformamide / 18 h

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011133d