1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone

Base Information

• Chemical Name: 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone
• CAS No.: 1607807-34-0
• Molecular Formula: C₁₉H₁₄F₃NOS
• Molecular Weight: 361.387

Synonyms:1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone

Chemical Property of 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone

There total 3 articles about 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-[2-(4-iodophenyl)-4-methylthiazol-5-yl]ethanone (1537168-69-6) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone (1607807-34-0)

Guidance literature:

With potassium phosphate; palladium diacetate; CyJohnPhos; In toluene; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.03.015

Reference yield:

4-iodobenzothioamide (106748-23-6) → 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone (1607807-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Reflux

2: potassium phosphate; palladium diacetate; CyJohnPhos / toluene / 24 h / 90 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; CyJohnPhos; In ethanol; toluene; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.ejmech.2015.03.015

Reference yield:

α-chloropentanedione → 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone (1607807-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Reflux

2: potassium phosphate; palladium diacetate; CyJohnPhos / toluene / 24 h / 90 °C / Inert atmosphere

With potassium phosphate; palladium diacetate; CyJohnPhos; In ethanol; toluene; 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.ejmech.2015.03.015

upstream raw materials:

4-iodobenzothioamide

1-[2-(4-iodophenyl)-4-methylthiazol-5-yl]ethanone

4-trifluoromethylphenylboronic acid

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