(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

Base Information

Chemical Name:(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane
CAS No.:1417332-39-8
Molecular Formula:C₁₅H₂₃BF₂O₂Si
Molecular Weight:312.24
Hs Code.:

Synonyms:(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

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Chemical Property of (2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

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Technology Process of (2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

There total 3 articles about (2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417332-30-9
(4-bromo-2,5-difluorophenyl)trimethylsilane

: 73183-34-3
bis(pinacol)diborane

: 1417332-39-8
(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 80 ℃; for 12h;

Reference yield:

: 73183-34-3
bis(pinacol)diborane

: 75186-45-7
(2,5-difluorophenyl)trimethylsilane

: 1417332-39-8
(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

: C₁₅H₂₃BF₂O₂Si

Guidance literature:: With (4-Me-^iPrPNP)Co(O₂C^tBu)₂; In tetrahydrofuran; at 60 ℃; for 24h; Overall yield = 60 percentSpectr.; regioselective reaction; Inert atmosphere; Glovebox; Sealed tube;
DOI:10.1016/j.chempr.2020.11.017

Reference yield:

: 327-51-5
1,4-dibromo-2,5-difluorobenzene

: 1417332-39-8
(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 12 h / 80 °C

With n-butyllithium; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In diethyl ether; hexane; dimethyl sulfoxide;