Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester
CAS No.:183239-98-7
Molecular Formula:C₅₄H₆₄ClNO₁₆S
Molecular Weight:1050.62
Hs Code.:

Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Synonyms:Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Suppliers and Price of Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

There total 12 articles about Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 183239-95-4
Succinic acid (2R,4aR,6R,7R,8S,8aR)-7-benzoyloxy-6-(5-benzyloxycarbonylamino-pentyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

: 183239-98-7
Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; diethyl ether; for 0.0833333h; Ambient temperature;
DOI:10.1002/jlac.199619961016

Reference yield:

: 100-39-0
benzyl bromide

: 183239-98-7
Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Bu₂SnO, molecular sieves 4 Angstroem, 2.) CsF / 1.) C₆H₆, reflux, 5 h, 2.) DMF, r.t., 5 h

2: 94 percent / DMAP, pyridine / 60 h / Ambient temperature

3: 88 percent / DCC, DMAP / CH₂Cl₂ / 26 h / Ambient temperature

4: 98 percent / aq. DDQ / CH₂Cl₂ / 16 h / Ambient temperature

5: 94 percent / pyridine / 1 h / 0 °C

6: 75 percent / HCl, NaCNBH₃ / tetrahydrofuran; diethyl ether / 0.08 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; 4 A molecular sieve; di(n-butyl)tin oxide; sodium cyanoborohydride; dicyclohexyl-carbodiimide; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/jlac.199619961016

Reference yield:

: 98-88-4
benzoyl chloride

: 183239-98-7
Succinic acid (2R,3R,4S,5R,6R)-3-benzoyloxy-2-(5-benzyloxycarbonylamino-pentyloxy)-6-benzyloxymethyl-5-hydroxy-tetrahydro-pyran-4-yl ester (2S,3R,4R,5S,6S)-4-benzyloxy-5-(2-chloro-acetoxy)-2-ethylsulfanyl-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / Bu₄NHSO₄, 5percent aq. NaOH / CH₂Cl₂ / 0.33 h / -4 °C

2: 88 percent / DCC, DMAP / CH₂Cl₂ / 26 h / Ambient temperature

3: 98 percent / aq. DDQ / CH₂Cl₂ / 16 h / Ambient temperature

4: 94 percent / pyridine / 1 h / 0 °C

5: 75 percent / HCl, NaCNBH₃ / tetrahydrofuran; diethyl ether / 0.08 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/jlac.199619961016