2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester

Base Information

• Chemical Name: 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester
• CAS No.: 1234571-06-2
• Molecular Formula: C₂₃H₂₆N₄O₄
• Molecular Weight: 422.484
• Mol file: 1234571-06-2.mol

Synonyms:2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester

Chemical Property of 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester

There total 3 articles about 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C15H20N2O2 (1234571-02-8) + anthranilic acid methyl ester hydrochloride (13516-02-4) → 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester (1234571-06-2)

Guidance literature:

anthranilic acid methyl ester hydrochloride; With water; sodium nitrite; Cooling;

C₁₅H₂₀N₂O₂; With sodium acetate; In ethanol; water; at 20 ℃; Cooling;

DOI:10.1016/j.ultsonch.2009.12.008

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester (1234571-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium cerium (IV) nitrate / 5 h / 40 °C / Sonication

2.1: water; sodium nitrite / Cooling

2.2: 20 °C / Cooling

With ammonium cerium (IV) nitrate; water; sodium nitrite;

DOI:10.1016/j.ultsonch.2009.12.008

Reference yield:

2-cyano-N-cyclohexylacetamide (15029-38-6) → 2-{2-[(3Z)-5-cyano-1-cyclohexyl-2,6-dioxo-4-propyl-1,6-dihydro-2H-pyridin-3-ylidene]hydrazin-1-yl}benzoic acid methyl ester (1234571-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.17 h / Microwave irradiation

2.1: water; sodium nitrite / Cooling

2.2: 20 °C / Cooling

With water; sodium nitrite;

DOI:10.1016/j.ultsonch.2009.12.008

upstream raw materials:

C₁₅H₂₀N₂O₂

anthranilic acid methyl ester hydrochloride

2-cyano-N-cyclohexylacetamide

cyclohexylamine

Downstream raw materials:

(7Z)-2-[2-(3-amino-5-cyclohexyl-1-ethyl-4,6-dioxo-5,6-dihydrothieno[3,4-c]pyridine-7(4H)-ylidene)hydrazinyl]benzoic acid methyl ester