1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

Base Information

Chemical Name:1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione
CAS No.:180900-32-7
Molecular Formula:C₃₄H₃₄O₈
Molecular Weight:570.639
Hs Code.:

Synonyms:1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

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Chemical Property of 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

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Technology Process of 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

There total 4 articles about 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 180900-30-5
2-(3,5-Bis-benzyloxy-4-methoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester

: 5101-00-8
4-(3,4,5-trimethoxyphenyl)-4-oxobutyric acid

: 19859-90-6
[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

: 180900-32-7
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

Guidance literature:: With sodium hydroxide; In ethanol; for 7h; Ambient temperature;
DOI:10.1016/0223-5234(96)89161-6

Reference yield:

: 19859-90-6
[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

: 180900-32-7
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / benzene; dimethylformamide / 1.25 h / 20 - 60 °C

2: 1.) LDA / 1.) THF, hexane, -60 deg C, 10 min, 2.) THF, hexane, -60 deg C, 30 min

3: 1.) NaH / 1.) Et₂O, reflux, 2.5 h, 2.) Et₂O, reflux, 4 h

4: 35 percent / 5percent aq. NaOH / ethanol / 7 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; sodium hydride; lithium diisopropyl amide; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0223-5234(96)89161-6

Reference yield:

: 19859-89-3
3,5-bis(benzyloxy)-4-methoxybenzoyl chloride

: 180900-32-7
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -60 deg C, 10 min, 2.) THF, hexane, -60 deg C, 30 min

2: 1.) NaH / 1.) Et₂O, reflux, 2.5 h, 2.) Et₂O, reflux, 4 h

3: 35 percent / 5percent aq. NaOH / ethanol / 7 h / Ambient temperature

With sodium hydroxide; sodium hydride; lithium diisopropyl amide; In ethanol;
DOI:10.1016/0223-5234(96)89161-6