1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Base Information

Chemical Name:1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol
CAS No.:180900-48-5
Molecular Formula:C₃₄H₃₈O₈
Molecular Weight:574.671
Hs Code.:

Synonyms:1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Suppliers and Price of 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

There total 5 articles about 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 180900-32-7
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione

: 180900-48-5
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 70 ℃; for 1.33333h;
DOI:10.1016/0223-5234(96)89161-6

Reference yield:

: 19859-89-3
3,5-bis(benzyloxy)-4-methoxybenzoyl chloride

: 180900-48-5
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexane, -60 deg C, 10 min, 2.) THF, hexane, -60 deg C, 30 min

2: 1.) NaH / 1.) Et₂O, reflux, 2.5 h, 2.) Et₂O, reflux, 4 h

3: 35 percent / 5percent aq. NaOH / ethanol / 7 h / Ambient temperature

4: 97 percent / NaBH₄ / ethanol / 1.33 h / 70 °C

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; lithium diisopropyl amide; In ethanol;
DOI:10.1016/0223-5234(96)89161-6

Reference yield:

: 19859-90-6
[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

: 180900-48-5
1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride / benzene; dimethylformamide / 1.25 h / 20 - 60 °C

2: 1.) LDA / 1.) THF, hexane, -60 deg C, 10 min, 2.) THF, hexane, -60 deg C, 30 min

3: 1.) NaH / 1.) Et₂O, reflux, 2.5 h, 2.) Et₂O, reflux, 4 h

4: 35 percent / 5percent aq. NaOH / ethanol / 7 h / Ambient temperature

5: 97 percent / NaBH₄ / ethanol / 1.33 h / 70 °C

With sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; sodium hydride; lithium diisopropyl amide; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0223-5234(96)89161-6