19859-89-3Relevant articles and documents
The synthesis of methylated epigallocatechin gallate
Lai, Ronghui,Zhao, Wenfang,Huang, Yahui,Zhou, Wen,Wu, Chunlan,Lai, Xingfei,Zhao, Wenxia,Zhang, Ming
, p. 472 - 475 (2015/12/26)
Synthesis of methylated epigallocatechin gallate from (-)-epigallocatechin gallate and propylgallate was accomplished using a benzyl (Bn) group as a protecting group for phenols. This methodology provided (-)-epigallocatechin-3-(4-O-methylgallate), which
Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins
Wan, Sheng Biao,Ping Dou,Chan, Tak Hang
, p. 5897 - 5904 (2007/10/03)
The regiospecific and enantioselective syntheses of various methylated regioisomers of epicatechin gallate (EGC) and epigallocatechin gallate (EGCG) have been achieved.
Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups
Smith,Blackwell,Demaine,Garland,Hodson,Hyde,Parke,Rose,Sawyer,Tilling
, p. 347 - 358 (2007/10/03)
This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.
N,N'-Heptamethylenebis(4-methoxybenzamide)
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, (2008/06/13)
4-(Q-O)-4'-R1 -N,N'-alkylenebis(benzamides), N,N'-alkylenebis(3,4-methylenedioxybenzamides) or N,N'-alkylenebis[4-(lower-alkoxy)benzamides], having endocrinological properties, where Q is lower-alkyl, lower-alkoxyalkyl, lower-alkenyl, halo-lower-alkyl, halo-lower-alkenyl, lower-cycloalkyl, phenyl and BN-(lower-alkyl) where BN is di-(lower-alkyl)amino or a saturated N-heteromonocyclic radical having from five to seven ring atoms and alkylene has at least five carbon atoms between its two connecting linkages and R1 is Q-O-, hydrogen, lower-alkoxy, lower-alkyl, halo, benzyloxy, hydroxy, di-(lower-alkyl)amino, nitro, amino or trihalomethyl are prepared preferably by reacting the appropriate diamine or N-(aminoalkyl)-benzamide with two or one molar equivalents, respectively, of the appropriate benzoyl halide.