C₂₇H₂₈N₆O₃S

Base Information

• Chemical Name: C₂₇H₂₈N₆O₃S
• CAS No.: 1439393-75-5
• Molecular Formula: C₂₇H₂₈N₆O₃S
• Molecular Weight: 516.624
• Mol file: 1439393-75-5.mol

Synonyms:C₂₇H₂₈N₆O₃S

Chemical Property of C₂₇H₂₈N₆O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₈N₆O₃S

There total 7 articles about C₂₇H₂₈N₆O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tropic acid (529-64-6,28845-94-5) + N-(6-(4-(5-amino-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)-2-phenylethanamide (1439394-33-8) → C27H28N6O3S (1439393-75-5)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

phenylacetyl chloride (103-80-0) → C27H28N6O3S (1439393-75-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-methyl-pyrrolidin-2-one / 1.58 h / 19 - 28 °C

2: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran / 4 h / 19 °C / Inert atmosphere

3: trifluoroacetic acid / 2 h / 65 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

N-(6-iodopyridazin-3-yl)-2-phenylacetamide (1439400-51-7) → C27H28N6O3S (1439393-75-5)

Guidance literature:

Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere

2: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol; ethyl acetate / 1 h

3: trifluoroacetic acid / 2 h / 65 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10 wt% Pd(OH)2 on carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

N-(6-iodopyridazin-3-yl)-2-phenylacetamide

pent-4-ynenitrile

C₁₇H₁₄N₄O

N-(6-(4-cyanobutyl)pyridazin-3-yl)-2-phenylacetamide