N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide
CAS No.:1448793-31-4
Molecular Formula:C₁₈H₁₆F₅N₅O₃
Molecular Weight:445.349
Hs Code.:

Synonyms:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

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Chemical Property of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

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Technology Process of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

There total 13 articles about N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1624605-50-0
N-(3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 1448793-31-4
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: In ethyl acetate;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1448793-31-4
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

9: ethyl acetate; N,N-dimethyl-formamide

10: ethyl acetate

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: (R,E)-N-(1-(5-bromo-2-fluorophenyl)-2-fluoroethylidene)-2-methylpropane-2-sulfinamide

: 1448793-31-4
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

2: sodium borohydrid; ammonia / tetrahydrofuran; methanol

3: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

4: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

5: hydrogenchloride / ethyl acetate; 1,4-dioxane

6: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

7: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

8: ethyl acetate; N,N-dimethyl-formamide

9: ethyl acetate

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;