1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

Base Information

Chemical Name:1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
CAS No.:1043468-82-1
Molecular Formula:C₂₆H₃₃ClO₁₀
Molecular Weight:540.995
Hs Code.:

Synonyms:1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

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Chemical Property of 1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

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Technology Process of 1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

There total 3 articles about 1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1043468-87-6
1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

: 1043468-82-1
1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

Guidance literature:: With Amberlyst 15; In tetrahydrofuran; methanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.057

Reference yield:

: 847682-00-2
1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

: 65178-90-7
2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropionyl chloride

: 1043468-82-1
1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: Amberlyst 15 / methanol; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With dmap; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.08.057

Reference yield:

: 847682-00-2
1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

: 42017-89-0
fenofibric acid

: 1043468-82-1
1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: Amberlyst 15 / methanol; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.08.057