Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester
CAS No.:173034-01-0
Molecular Formula:C₃₄H₃₄N₅O₈P
Molecular Weight:671.646
Hs Code.:

Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Synonyms:Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

There total 2 articles about Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1707-03-5
diphenyl-phosphinic acid

: 173033-98-2
Benzoic acid (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-methylsulfanylmethoxymethyl-tetrahydro-furan-3-yl ester

: 173034-01-0
Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With N-iodo-succinimide; In diethyl ether; 1,2-dichloro-ethane; Ambient temperature;
DOI:10.1016/0040-4039(95)01809-V

Reference yield:

: 63660-23-1
3'-O-benzoyl-N²-isobutyryl-2'-deoxyguanosine

: 173034-01-0
Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Bz₂O₂

2: 70 percent / N-iodosuccinimide (NIS) / 1,2-dichloro-ethane; diethyl ether / Ambient temperature

With N-iodo-succinimide; dibenzoyl peroxide; In diethyl ether; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(95)01809-V

Reference yield: 55.0%

: 123126-01-2
3'-mercapto-5'-O-DMT-3'-deoxythymidine

: 173034-01-0
Benzoic acid (2R,3S,5R)-2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: C₅₃H₅₅N₇O₁₂S

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In formamide; N,N-dimethyl-formamide; Ambient temperature; under N₂ or Ar;
DOI:10.1016/0040-4039(95)01809-V