methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

Base Information

Chemical Name:methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate
CAS No.:1168090-87-6
Molecular Formula:C₁₆H₁₈ClFN₂O₂Si
Molecular Weight:352.868
Hs Code.:

Synonyms:methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

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Chemical Property of methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

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Technology Process of methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

There total 3 articles about methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 67-56-1
methanol

: 1168090-86-5
6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinic acid

: 1168090-87-6
methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

Guidance literature:: 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 0.5h;

methanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.25h;

Reference yield:

: 955372-99-3
2-fluoro-4-trimethylsilanylphenylamine

: 1168090-87-6
methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

2.2: 0.5 h / 0 - 20 °C

2.3: 0.25 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1168090-87-6
methyl 6-chloro-2-((2-fluoro-4-(trimethylsilyl)phenyl)amino)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

3.2: 0.5 h / 0 - 20 °C

3.3: 0.25 h / 0 - 20 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;