Technology Process of 3-phenyl-3-(pyridazin-4-yl)propanoic acid
There total 5 articles about 3-phenyl-3-(pyridazin-4-yl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 3-phenyl-3-(pyridazin-4-yl)propanoate;
With
water; sodium hydroxide;
In
methanol;
With
hydrogenchloride;
In
water;
pH=4-5;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; silver nitrate; ammonium persulfate / water / 1.5 h / 60 - 90 °C
2.1: selenium(IV) oxide; acetic acid / 1 h / 100 °C
3.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C
3.2: 4 h / 0 °C
4.1: benzenesufonyl hydrazide; triethylamine / toluene / 100 °C
5.1: sodium hydroxide; water / methanol
5.2: pH 4-5
With
selenium(IV) oxide; ammonium persulfate; sulfuric acid; water; sodium hydride; silver nitrate; acetic acid; triethylamine; benzenesufonyl hydrazide; sodium hydroxide;
In
tetrahydrofuran; methanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C
1.2: 4 h / 0 °C
2.1: benzenesufonyl hydrazide; triethylamine / toluene / 100 °C
3.1: sodium hydroxide; water / methanol
3.2: pH 4-5
With
water; sodium hydride; triethylamine; benzenesufonyl hydrazide; sodium hydroxide;
In
tetrahydrofuran; methanol; toluene;
