7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine

Base Information

• Chemical Name: 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine
• CAS No.: 1433368-79-6
• Molecular Formula: C₂₉H₃₃ClN₄O₃SeSi
• Molecular Weight: 628.105

Synonyms:7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine

Chemical Property of 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine

There total 12 articles about 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

acetic acid 6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl ester (1006032-32-1) + 6-chloro-7H-purine (87-42-3,111055-92-6) → 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine (1433368-79-6) + 9-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-9H-purine (1433368-71-8)

Guidance literature:

6-chloro-7H-purine; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; at 95 ℃; for 1h; Inert atmosphere;

acetic acid 6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl ester; With trimethylsilyl trifluoromethanesulfonate; In toluene; at 95 ℃; for 15h; Solvent; Temperature; Concentration; Inert atmosphere;

DOI:10.1002/chem.201300741

Reference yield:

(3aS,4R,6aR)-tetrahydro-4-([(tert-butyl)dimethylsilyloxy]methyl)-2,2-dimethylselenopheno[3,4-d][1,3]dioxole (1006032-30-9) → 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine (1433368-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

2.1: 1 h / 100 °C / Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene; 1,2-dichloro-ethane / Inert atmosphere

3.2: 15 h / 85 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1002/chem.201300741

Reference yield:

2,3-O-isopropylidene-L-lyxono-1,4-lactone (152006-17-2) → 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine (1433368-79-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine; dmap / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate; selenium / ethanol; tetrahydrofuran / 15 h / 60 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

6.1: 1 h / 100 °C / Inert atmosphere

7.1: N,O-bis-(trimethylsilyl)-acetamide / toluene; 1,2-dichloro-ethane / Inert atmosphere

7.2: 15 h / 85 °C / Inert atmosphere

With dmap; selenium; sodium tetrahydroborate; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1002/chem.201300741

upstream raw materials:

tert-butylchlorodiphenylsilane

5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol

5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1,4-di-O-methanesulfonyl-L-lyxitol

(3aS,4R,6aR)-tetrahydro-4-([(tert-butyl)dimethylsilyloxy]methyl)-2,2-dimethylselenopheno[3,4-d][1,3]dioxole

Downstream raw materials:

9-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-9H-purine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1433368-79-6 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine

Send

Send

Metric Ton KG G Pound L ML

Send

Send