(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Base Information

Chemical Name:(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate
CAS No.:1374003-14-1
Molecular Formula:C₁₃H₁₃Cl₃N₂O₄
Molecular Weight:367.616
Hs Code.:

Synonyms:(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Suppliers and Price of (R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

There total 5 articles about (R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 100-13-0
4-nitrostyrene

: 1374003-05-0
1,1,1-trichloro-2-methylpropan-2-yl (tosyloxy)carbamate

: 1374003-14-1
(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (4R,4'R)-2,2'-(propane-2,2-diyl)bis(5,5-dimethyl-4-phenyl-4,5-dihydrooxazole); potassium carbonate; In acetonitrile; at 23 ℃; for 14h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tet.2012.02.044

Reference yield:

: C₅H₈Cl₃NO₃

: 1374003-14-1
(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2: tetrakis(actonitrile)copper(I) hexafluorophosphate; C₂₅H₃₀N₂O₂; potassium carbonate / acetonitrile / 14 h / 23 °C / Inert atmosphere; Molecular sieve

With tetrakis(actonitrile)copper(I) hexafluorophosphate; C₂₅H₃₀N₂O₂; potassium carbonate; triethylamine; In diethyl ether; acetonitrile;
DOI:10.1016/j.tet.2012.02.044

Reference yield:

: 1346641-42-6
3,3,3-trichloro-2-methyl-2-propyl imidazole-1-carboxylate

: 1374003-14-1
(R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 0.5 h / 20 °C / Inert atmosphere

2: 1H-imidazole / acetonitrile / 2 h / 60 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 16 h

4: triethylamine / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

5: tetrakis(actonitrile)copper(I) hexafluorophosphate; C₂₅H₃₀N₂O₂; potassium carbonate / acetonitrile / 14 h / 23 °C / Inert atmosphere; Molecular sieve

With 1H-imidazole; tetrakis(actonitrile)copper(I) hexafluorophosphate; palladium 10% on activated carbon; C₂₅H₃₀N₂O₂; hydrogen; potassium carbonate; triethylamine; In methanol; diethyl ether; acetone; acetonitrile;
DOI:10.1016/j.tet.2012.02.044