4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester
• CAS No.: 1044872-32-3
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 1044872-32-3.mol

Synonyms:4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

Chemical Property of 4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

There total 1 articles about 4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-methyl-piperazine (109-01-3) + Ethyl 4-(bromomethyl)benzoate (26496-94-6) → 4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester (1044872-32-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield: 92.0%

4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester (1044872-32-3) + 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (152460-10-1) → imatinib (152459-95-5)

Guidance literature:

With sodium methylate; In dichloromethane; at 40 ℃;

Reference yield: 67.0%

4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester (1044872-32-3) → (4-(4-methyl piperazin-1-ylmethyl)phenyl)-methanol (622381-65-1)

Guidance literature:

4-(4-methyl piperazin-1-ylmethyl)-benzoic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

1-methyl-piperazine

Ethyl 4-(bromomethyl)benzoate

Downstream raw materials:

(4-(4-methyl piperazin-1-ylmethyl)phenyl)-methanol

imatinib

4-((4-methylpiperazin-1-yl)methyl)benzaldehyde