2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI)

Base Information

• Chemical Name: 2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI)
• CAS No.: 176244-21-6
• Molecular Formula: C7H4 F2 N2 O
• Molecular Weight: 170.118
• Mol file: 176244-21-6.mol

Synonyms:2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI)

Chemical Property of 2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI)

Chemical Property:

• PSA: 48.91000
• LogP: 1.54670
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

5,6-Difluoro-1,3-dihydro-2H-benzimidazol-2-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI)

There total 3 articles about 2H-Benzimidazol-2-one,5,6-difluoro-1,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-4,5-difluoroaniline (76179-40-3) + 1,1'-carbonyldiimidazole (530-62-1) → 5,6-difluoro-1H-benzo[d]imidazol-2(3H)-one (176244-21-6)

Guidance literature:

In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1021/ja952836l

Reference yield:

2-amino-4,5-difluoroaniline (76179-40-3) + urea (57-13-6) → 5,6-difluoro-1H-benzo[d]imidazol-2(3H)-one (176244-21-6)

Guidance literature:

In tetrahydrofuran; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.1c00354

Reference yield:

→ 5,6-difluoro-1H-benzo[d]imidazol-2(3H)-one (176244-21-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

upstream raw materials:

2-amino-4,5-difluoroaniline

1,1'-carbonyldiimidazole

urea

Downstream raw materials:

2-Chloro-5,6-difulorobenzimidazole

Refernces

• 1、 Dziwornu, Godwin Akpeko,Coertzen, Dina,Leshabane, Meta,Korkor, Constance M.,Cloete, Cleavon K.,Njoroge, Mathew,Gibhard, Liezl,Lawrence, Nina,Reader, Janette,Van Der Watt, Mari?tte,Wittlin, Sergio,Birkholtz, Lyn-Marie,Chibale, Kelly. "Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and in Vivo Oral Efficacy Studies". . p. 5198 - 5215. Retrieved 2021/05/06.
• 2、 -. "INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS". Page/Page column 49-50. . Retrieved 2010/09/17.