1H-Benzimidazole,2-chloro-5,6-difluoro-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-chloro-5,6-difluoro-(9CI)
• CAS No.: 142356-63-6
• Molecular Formula: C7H3 Cl F2 N2
• Molecular Weight: 188.564
• Mol file: 142356-63-6.mol

Synonyms:2-Chloro-5,6-difluoro-1H-benzimidazole;2-Chloro-5,6-difluorobenzimidazole

Chemical Property of 1H-Benzimidazole,2-chloro-5,6-difluoro-(9CI)

Chemical Property:

• PSA: 28.68000
• LogP: 2.49450

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-5,6-Difluoro-1H-Benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-chloro-5,6-difluoro-(9CI)

There total 6 articles about 1H-Benzimidazole,2-chloro-5,6-difluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5,6-difluoro-1H-benzo[d]imidazol-2-amine (142356-62-5) → 2-Chloro-5,6-difulorobenzimidazole (142356-63-6)

Guidance literature:

With tert.-butylnitrite; copper dichloride; In acetone; at 20 ℃; for 0.333333h;

5,6-difluoro-1H-benzo[d]imidazol-2-amine; In acetone; for 2h; Heating / reflux;

With hydrogenchloride; In water; acetone; at 20 ℃;

Reference yield:

2-amino-4,5-difluoroaniline (76179-40-3) → 2-Chloro-5,6-difulorobenzimidazole (142356-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile; H₂O; methanol / 2 h / Ambient temperature

2: 59 percent / aq. CuCl₂, NaNO₂ / a) RT, 1 h, b) 100 deg C, 10 min

With copper dichloride; sodium nitrite; In methanol; water; acetonitrile;

DOI:10.1021/jm960462g

Reference yield:

5,6-difluoro-1H-benzo[d]imidazol-2(3H)-one (176244-21-6) → 2-Chloro-5,6-difulorobenzimidazole (142356-63-6)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃;

DOI:10.1016/j.bmcl.2008.08.018

upstream raw materials:

5,6-difluoro-1H-benzo[d]imidazol-2-amine

4,5-difluoro-2-nitroaniline

2-amino-4,5-difluoroaniline

water

Downstream raw materials:

6-(5,6-difluoro-1H-benzimidazol-2-yl)-3-phenyl-2-[(phenylmethyl)thio]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one