N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Base Information

Chemical Name:N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide
CAS No.:907181-00-4
Molecular Formula:C₁₅H₁₀Cl₂N₄O₄
Molecular Weight:381.175
Hs Code.:

<i>N</i>-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-<i>b</i>]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Synonyms:N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

There total 6 articles about N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 907180-99-8
N-(3-amino-5-methoxy-phenyl)-acetamide

: 144692-85-3
5,6-dichloropyrazine-2,3-dicarboxylic acid anhydride

: 907181-00-4
N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Guidance literature:: N-(3-amino-5-methoxy-phenyl)-acetamide; 5,6-dichloropyrazine-2,3-dicarboxylic acid anhydride; In tetrahydrofuran; at 20 ℃; for 4h;

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 2h;

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/ol0612760

Reference yield:

: 292635-40-6
3-methoxy-5-nitrobenzamide

: 907181-00-4
N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOBr / methanol / 1.5 h / 20 °C

1.2: 84 percent / aq. NaHCO₃ / 2 h / 80 °C

2.1: 76 percent / CH₂Cl₂ / 12 h

3.1: 99 percent / Cu(acac)2; NaBH₄ / ethanol; methanol / 12 h / 20 °C

4.1: tetrahydrofuran / 4 h / 20 °C

4.2: (COCl)2; DMF / tetrahydrofuran / 2 h

4.3: 71 percent / pyridine; (COCl)2; DMF / tetrahydrofuran / 12 h / 20 °C

With copper acetylacetonate; sodium tetrahydroborate; sodium hypobromide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ol0612760

Reference yield:

: 586-10-7
3-methoxy-5-nitroaniline

: 907181-00-4
N-[3-(2,3-dichloro-5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyrazin-6-yl)-5-methoxy-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / CH₂Cl₂ / 12 h

2.1: 99 percent / Cu(acac)2; NaBH₄ / ethanol; methanol / 12 h / 20 °C

3.1: tetrahydrofuran / 4 h / 20 °C

3.2: (COCl)2; DMF / tetrahydrofuran / 2 h

3.3: 71 percent / pyridine; (COCl)2; DMF / tetrahydrofuran / 12 h / 20 °C

With copper acetylacetonate; sodium tetrahydroborate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ol0612760