(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

Base Information

Chemical Name:(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate
CAS No.:1227307-24-5
Molecular Formula:C₂₅H₄₅O₆PSi
Molecular Weight:500.688
Hs Code.:

Synonyms:(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

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Technology Process of (Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

There total 6 articles about (Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1227307-15-4
(Z)-diethyl 2-hydroxy-6-(4-methoxy benzyloxy)-4-methyl hex-4-enyl phosphonate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1227307-24-5
(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol100665m

Reference yield:

: 1227307-14-3
(Z)-1-chloro-6-(4-methoxybenzyloxy)-4-methylhex-4-en-2-ol

: 1227307-24-5
(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / 20 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 6 h / -78 °C

3.1: dmap / N,N-dimethyl-formamide / 36 h / 20 °C

With dmap; n-butyllithium; potassium hydroxide; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201202553

Reference yield:

: 1227307-23-4
(Z)-2-(4-(4-methoxybenzyloxy)-2-methylbut-2-enyl)oxirane

: 1227307-24-5
(Z)-diethyl 2-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-4-methylhex-4-enylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 6 h / -78 °C

2.1: dmap / N,N-dimethyl-formamide / 36 h / 20 °C

With dmap; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201202553